Michael P Whyte Selected Research

Enzymes

1/2023	Carbonic anhydrase II deficiency.
1/2018	Alkaline Phosphatase: Discovery and Naming of Our Favorite Enzyme.
8/2012	Enzyme replacement prevents enamel defects in hypophosphatasia mice.
5/2012	"Atypical femoral fractures" during bisphosphonate exposure in adult hypophosphatasia.
8/2011	Dose response of bone-targeted enzyme replacement for murine hypophosphatasia.
4/2010	Upregulation of elastase activity in aorta in mucopolysaccharidosis I and VII dogs may be due to increased cytokine expression.

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Michael P Whyte Research Topics

Disease

46	Hypophosphatasia 01/2024 - 01/2002
31	Rickets (Rachitis) 01/2024 - 04/2003
23	Osteomalacia 01/2024 - 11/2006
12	Metabolic Bone Diseases (Osteopenia) 01/2024 - 08/2007
11	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2024 - 06/2009
10	Congenital Abnormalities (Deformity) 01/2024 - 09/2008
10	Pain (Aches) 01/2021 - 10/2008
8	Infantile Hypophosphatasia 01/2019 - 02/2002
7	Bone Diseases (Bone Disease) 01/2023 - 09/2008
7	Osteopetrosis 01/2023 - 07/2003
7	Hypercalcemia (Milk Alkali Syndrome) 11/2018 - 06/2007
6	Tooth Loss 01/2024 - 04/2014
6	Hyperostosis corticalis deformans juvenilis 01/2023 - 07/2002
6	Osteoporosis 01/2020 - 11/2006
5	Adult Hypophosphatasia 12/2021 - 04/2007
4	Osteosclerosis 01/2020 - 10/2008
4	Craniosynostoses (Craniosynostosis) 01/2019 - 06/2015
4	Femoral Fractures (Femoral Fracture) 01/2014 - 11/2006
3	Muscle Weakness 01/2024 - 01/2016
3	Disease Progression 01/2023 - 06/2007
3	hereditary expansile Polyostotic osteolytic dysplasia 01/2023 - 04/2014
3	Hypophosphatemia 01/2022 - 02/2013
3	Seizures (Absence Seizure) 01/2022 - 06/2007
3	Arterial calcification of infancy 01/2020 - 02/2013
3	Hyperphosphatemia 01/2020 - 04/2007
3	Joint Diseases (Joint Disease) 09/2017 - 04/2014
3	Pyridoxine-dependent epilepsy 09/2017 - 06/2008
3	Osteitis Deformans (Paget's Disease of Bone) 11/2014 - 04/2004
3	Neoplasms (Cancer) 04/2014 - 10/2005
3	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 03/2008 - 04/2004
2	Osteogenesis Imperfecta (Lobstein Disease) 01/2023 - 06/2011
2	Hypocalcemia 01/2023 - 01/2021
2	Secondary Hyperparathyroidism 01/2021 - 08/2011
2	Hepatitis C 01/2021 - 01/2016
2	Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome) 01/2020 - 01/2019
2	X-Linked Hypoparathyroidism 01/2020 - 12/2004
2	Failure to Thrive 01/2020 - 01/2019
2	Hyperostosis 01/2020 - 05/2007
2	Contracture 01/2020 - 02/2013
2	Enthesopathy 01/2020 - 01/2019
2	Respiratory Insufficiency (Respiratory Failure) 01/2019 - 01/2013
2	Periarthritis 01/2019 - 04/2014
2	Arthritis (Polyarthritis) 11/2018 - 10/2005
2	Arthralgia (Joint Pain) 11/2018 - 08/2011
2	Nephrocalcinosis 11/2018 - 06/2007
2	Body Weight (Weight, Body) 01/2018 - 08/2011
2	Primary Myelofibrosis (Myelosclerosis) 01/2016 - 09/2012
2	Frontotemporal Dementia (Semantic Dementia) 03/2008 - 04/2004
2	Muscular Diseases (Myopathy) 03/2008 - 04/2004
1	Sensorineural Hearing Loss 01/2023
1	Familial Paget's disease of bone 01/2023

Drug/Important Bio-Agent (IBA)

47	Alkaline PhosphataseIBA 01/2024 - 01/2002
35	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 01/2024 - 06/2006
32	IsoenzymesIBA 01/2024 - 02/2002
13	Phosphates (Orthophosphate)IBA 01/2024 - 01/2016
12	diphosphoric acid (pyrophosphoric acid)IBA 01/2021 - 06/2007
10	PyridoxalIBA 01/2021 - 01/2002
9	burosumabIBA 01/2024 - 01/2018
9	Vitamin D FDA LinkGeneric 10/2023 - 05/2011
9	CalciumIBA 01/2020 - 09/2012
8	Diphosphonates (Bisphosphonates)IBA 01/2023 - 07/2003
8	asfotase alfaIBA 01/2021 - 08/2011
7	Vitamin B 6IBA 01/2024 - 06/2007
7	Fibroblast Growth Factor-23IBA 01/2022 - 12/2005
6	EnzymesIBA 01/2023 - 04/2010
6	Monoclonal AntibodiesIBA 01/2022 - 09/2012
6	MineralsIBA 01/2022 - 12/2013
6	Durapatite (Hydroxylapatite)IBA 01/2019 - 08/2009
5	Phosphorus (Red Phosphorus)IBA 01/2021 - 01/2018
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2002
5	OsteoprotegerinIBA 04/2016 - 07/2002
4	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/2023 - 05/2007
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 02/2002
4	Biomarkers (Surrogate Marker)IBA 11/2018 - 04/2007
4	Pamidronate (Aredia)FDA LinkGeneric 12/2014 - 10/2008
3	Teriparatide (Parathar)FDA Link 12/2021 - 04/2007
3	Parathyroid Hormone (Parathormone)IBA 01/2020 - 08/2016
3	Tetracycline (Achromycin)FDA LinkGeneric 01/2017 - 01/2007
3	RANK LigandIBA 09/2012 - 07/2002
2	Pyridoxine (Pyridoxin)FDA LinkGeneric 01/2024 - 06/2007
2	Zoledronic Acid (Zometa)FDA Link 01/2023 - 01/2023
2	Receptor Activator of Nuclear Factor-kappa B (TRANCE-R)IBA 01/2023 - 05/2007
2	PHEX Phosphate Regulating Neutral EndopeptidaseIBA 12/2022 - 01/2019
2	TeaIBA 01/2021 - 08/2011
2	hydroxide ionIBA 01/2020 - 08/2011
2	Protein Isoforms (Isoforms)IBA 01/2020 - 02/2013
2	alpha2 Subunit Collagen Type IIBA 01/2020 - 06/2011
2	OsteopontinIBA 01/2020 - 01/2017
2	CreatinineIBA 01/2019 - 01/2002
2	phosphorylethanolamine (phosphoethanolamine)IBA 08/2016 - 06/2007
2	Protein Sorting Signals (Signal Peptide)IBA 11/2014 - 04/2014
2	OsteocalcinIBA 02/2013 - 02/2005
2	GlucuronidaseIBA 09/2012 - 04/2010
2	GlycosaminoglycansIBA 09/2012 - 04/2010
2	VitaminsIBA 08/2012 - 01/2002
2	Valosin Containing ProteinIBA 02/2006 - 04/2004
1	BuffersIBA 01/2024
1	Carbonic Anhydrase IIIBA 01/2023

Therapy/Procedure

18	Therapeutics 01/2024 - 11/2006
4	Enzyme Replacement Therapy 01/2019 - 06/2008